MDR PowerFactors™
What is in it, at what amounts, what published research shows at those amounts and what it does not, and what it costs.
The full label
Transcribed from the Nutrition Facts panel on the label.
Serving size 5.85 g (approx. 1 level scoop) · 25 servings per container
| Ingredient | Per serving | % DV |
|---|---|---|
| Calories | 0 | * |
| Total Carbohydrate | 0 g | * |
| Total Sugars | 0 g | * |
| Magnesium (as Magnesium Bisglycinate) | 100 mg | 24% |
| Creatine Monohydrate | 5 g | * |
| Collagen Peptides | 100 mg | * |
| NMN (as Nicotinamide Mononucleotide) | 250 mg | * |
What the research shows at these amounts
Here is what published human studies have found for each ingredient at or near the amount in one scoop, and what they have not found. Where a study used a different amount, we say so. These are studies of the single ingredients, not of PowerFactors itself.
Creatine monohydrate, 5 g
Creatine monohydrate is one of the most studied supplements there is. Research uses 3 to 5 grams a day to fill and keep up the creatine stores in muscle, which takes about three to four weeks of daily use. The International Society of Sports Nutrition reviewed the safety research and found it well tolerated in healthy people.
In adults over 50 who did resistance training, two analyses that pooled the trials found more gains in strength and lean muscle with creatine than with training alone.
Your brain uses creatine too. A 2023 analysis that pooled eight trials found a small overall benefit to memory, larger in adults aged 66 to 76, though the trials differed a lot. In a six-week trial of 123 adults taking 5 grams a day, the effect on thinking tests was small and fell short of statistical significance.
What it does not show: Most of the strength research pairs creatine with regular resistance exercise. The brain research is early and the effects so far are modest.
- Kreider et al., Journal of the International Society of Sports Nutrition (2017). Position stand on creatine: 3 to 5 g a day maintains muscle stores; safe and well tolerated in healthy people in short and long-term use.
- Chilibeck et al., Open Access Journal of Sports Medicine (2017). Meta-analysis of 22 trials, 721 adults with average ages of 57 to 70 doing resistance training: creatine added about 1.4 kg of lean mass and more chest and leg press strength than training alone.
- Devries and Phillips, Medicine & Science in Sports & Exercise (2014). Meta-analysis of 357 older adults (average age about 64) over about 12 weeks of training: creatine improved chest press, leg press and the chair-stand test; several other strength measures did not differ.
- Prokopidis et al., Nutrition Reviews (2023). Meta-analysis of 8 trials in healthy people: a small overall benefit to memory, larger in adults aged 66 to 76; results varied widely between trials.
- Sandkühler et al., BMC Medicine (2023). 123 adults, 5 g a day for six weeks against placebo: a small effect on a memory test that did not reach statistical significance, and none on a reasoning test.
NMN (nicotinamide mononucleotide), 250 mg
Your cells use NMN to make NAD+, a molecule involved in turning food into energy. NAD+ levels tend to fall as we get older.
In a 12-week placebo-controlled trial of 30 healthy adults, 250 mg of NMN a day raised NAD+ in the blood, and no adverse effects were seen in the 15 people taking it. In a trial of men aged 65 and over (42 enrolled; a supplement mix-up left 20 in the 12-week analysis), the same amount also raised blood NAD+; walking speed and left-hand grip strength improved slightly, muscle mass did not change, and the authors said larger studies are needed.
In September 2025 the FDA concluded that NMN is not excluded from the definition of a dietary supplement. That removed the drug-exclusion barrier. It is not an FDA approval: the FDA does not approve supplements for safety or effectiveness, and makers remain responsible for both.
What it does not show: Raising NAD+ in the blood is well documented. What that means for how you feel or function day to day has not been shown in large trials. A 24-week trial published in September 2026 gave adults aged 65 and over five times this amount (1,250 mg a day): blood NAD+ rose, but hearing and physical performance did not improve.
- Okabe et al., Frontiers in Nutrition (2022). 30 healthy adults, 250 mg a day or placebo for 12 weeks: whole-blood NAD+ rose with NMN; no adverse effects or abnormal lab results were seen in the 15 taking NMN.
- Igarashi et al., npj Aging (2022). 42 healthy men aged 65 and over enrolled (20 in the 12-week analysis after a supplement allocation error), 250 mg a day or placebo: blood NAD+ rose; small gains in gait speed and left grip, no change in body composition. Exploratory results the authors say need larger studies.
- Igarashi et al., npj Aging (2026). Adults aged 65 and over, 1,250 mg a day or placebo for 24 weeks: NAD+ and related compounds rose; no significant improvement in hearing (the main measure) or physical performance.
- U.S. FDA response to citizen petition FDA-2023-P-0872 (September 29, 2025). FDA concluded that NMN is not excluded from the dietary supplement definition, because it was sold as a supplement before it was studied as a drug.
Magnesium (as magnesium bisglycinate), 100 mg
Magnesium supports normal muscle and nerve function and the body's energy production. Adults need 310 to 420 mg a day, and about half of Americans get less than they should from food.
100 mg is a top-up: about a quarter of the daily value, and well under the 350 mg a day the NIH sets as the upper limit for magnesium from supplements.
What it does not show: 100 mg is about a quarter of a day's need, so food is still the main source.
- NIH Office of Dietary Supplements, Magnesium fact sheet for health professionals. Recommended intakes (310 to 420 mg for adults), the 350 mg upper limit for supplemental magnesium, the finding that 48% of Americans take in less than the average requirement from food, and interactions with some antibiotics and bisphosphonates.
Collagen peptides, 100 mg
Collagen peptides are listed on the label at 100 mg. That is far below the 2.5 to 10 grams a day used in most collagen studies, so we make no claims for them.
- Pu et al., Nutrients (2023). Review of 26 collagen trials: most used 2.5 to 10 g a day; the lowest amount in any trial was about 0.4 g.
The combination
No clinical trial has tested PowerFactors or this exact combination. What it offers is convenience: creatine, NMN and magnesium in one scoop instead of three separate products.
What a serving costs
A jar holds 25 scoops. On Subscribe & Save it is $53.96 a jar, about $2.16 a scoop, with free shipping, delivered every 4 weeks. Bought once, a jar is $59.95, about $2.40 a scoop, plus $6.95 shipping unless the order has 3 or more items.
If you already buy creatine, NMN and magnesium separately and are happy with them, you may not need PowerFactors. If creatine is all you want, plain creatine monohydrate costs less.
Sources last checked October 2026.
Why it’s built this way
PowerFactors was made for people who would rather take one thing than three. One level scoop holds the daily amount of creatine monohydrate most research uses. It adds NMN at the amount used in several human trials, and a magnesium top-up in the bisglycinate form.
The label also lists a small amount of collagen peptides, and MDR makes no claims for them.
It is a powder you stir into juice or a protein shake, once a day. The full facts panel from the jar is transcribed above.
Good to know
- Full Nutrition Facts panel transcribed on this page
- Zero calories and zero sugar per scoop
- 25 servings per jar
- From MDR, an American company with 40 years in nutrition science
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.