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Est. 1984 in the USADaily wellness, refined.

Daily nutrition,
made simple.

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4.9 across 220 published reviews · over 2 million customers

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  • Doctor-formulated since 1984
  • Over 2 million customers
  • Original AM + PM system
  • 90-day guarantee

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Real customers

From the people who take MDR.

Fitness and nutrition go hand in hand — that’s why I take VitalFactors as my favorite natural energizer.

Chris CuomoNewsNation primetime anchor

VitalFactors is part of my training routine. I’ve run the Badwater 135-mile ultramarathon in Death Valley 12 times, and I rely on VitalFactors and other MDR products to stay physically active.

Frank McKinneyLong-time MDR customer
Nick MurtaPersonal trainer and owner of Catalyst Gym
Dr. Lisa LearnBoard-certified plastic surgeon and practice owner

I’ve been taking VitalFactors and other MDR vitamins for over 20 years. I topped the charts before Elvis, and I’m still active and strong today — it’s been part of my routine the whole way.

Pat BooneAmerican singer-songwriter and actor

I use the MDR Fitness Tablets in conjunction with the MDR Stress Release Tabs and have taken them for over 25 years. Excellent products.

Bill S.Amazon customer

…and two hundred more, published word for word since 2012.

This is a great formula….i love that the capsule is so small and goes down easily with no after taste. I do feel more flexible and my last physical with the doctor shows i am in great sha…
LauraPristinium Antarctic Krill · October 2025
I have been taking these MDR vitamins for years! I feel so good all the time...these are worth the money for sure.
Faye W.Fitness Tabs for Women · August 2024
Stress Defense is the best. I’m not sure if they reduce the stress in my life but they certainly give me the energy to deal with everything!
Kara K.Stress Defense Performance Tabs · June 2024
Referred to these by my 85-year-old mother. Always had problems with oily skin. Within a week, my skin cleared up and my energy level was off the charts. Excellent product.
LeslieFitness Tabs for Women · November 2023
I was taking Vision Formula for a few years and noticed my vision was clearer and better. I quit taking it and tried a cheaper supplement and noticed my eyesight was getting blurry and no…
WaltVision Formula · January 2023
Have tried others but always come back to MDR
M S.Fitness Tabs for Men · December 2022
I’m enjoying the vitamins and see the benefit of them
Chris P.Fitness Tabs for Women · December 2022
THIS PRODUCT IS WAY BETTER THAN ALL MY EXPECTATIONS. IT IS MY FAVORITE SUPPLIMENT. I AM 71. THANK YOU
JAY M.VitalFactors · November 2022
This product makes my brain and body work better. At my annual medical checkup, the numbers from my bloodwork all exceeded required minimums. The doctor and I were both impressed. Happy,…
Alan H.Fitness Tabs for Men · September 2022
Been using the Fitness tabs and these for 30+ years. Simply the Best
M S.Stress Defense Performance Tabs · August 2022
Best , will make you feel better and think clearer all day .
Glenn G.Fitness Tabs for Men · July 2022
These are the best vitamins we have ever taken, Have tried others but always come back to these
M S.Fitness Tabs for Women · June 2022
We have more energy and calmness simultaneously. Great bargain and products
B,C.Fitness Tabs for Men · May 2022
This is an outstanding supplement. It truly seems to stabilize my heart in these stressful times.
Cristi R.Stress Defense Performance Tabs · May 2022
I have been taking VitalFactors for several years now and I can say I definitely see and feel the difference! I follow the recommended usage of five days on/two days off and it is working…
John R.VitalFactors · April 2022
I believe these to be a very good value. At $1.19 per day for vitamins and stress defense for both men and women. Would be even less per day if both parties would be consistent in taking…
Karen K.Fitness Tabs for Women · March 2022
Simply the best! I've been taking the Fitness Tabs for more than 10 years and wouldn't consider any other brand.
Chris from O.Fitness Tabs for Women · November 2021
Thanks to MDR!!! Feeling better then ever since taking this wonderful formula!!
Lilly V.OnGuard Immune Defense · November 2021
I will never be without OnGuard. It has kept me well year round for the first time in my life and I travel a great deal. I recommend it to all my friends to keep them healthy. This is an…
Chris, F.OnGuard Immune Defense · November 2021
I'm a loyal Women's Fitness Tabs fan. I've been taking the Fitness Tabs for 20 years. I feel that I'm doing something important for my health by doing so and I have the added benefit of g…
Chris from O.Fitness Tabs for Women · October 2021
I know Pristinium fish oil which has the highest grade ingredients is good for my heart, my brain and my joints. It keeps my skin looking great as well.
Gloria, F.Pristinium Antarctic Krill · September 2021
I have been using these each day for years and will continue !
mike H.Longevity Antioxidants · August 2021
Can't say enough on this high-quality product my energy feels grate taking these tab AM/PM is the best? Thank you MDR
Sonny S.Fitness Tabs for Men · September 2024
Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling…
Kara K.VitalFactors · June 2024
Huge fan of Fitness Tab for Women. My energy has been through the roof and I have never felt better.
Gabby S.Fitness Tabs for Women · May 2024
I appreciate the fact you removed titanium dioxide from your formula and added Iodine. I came back to this product because you removed titanium dioxide and iodine is a necessary nutrient.…
Brian O R.Fitness Tabs for Men · January 2023
At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish m…
Judith H.VitalFactors · December 2022
Have tried others but always come back to MDR
M S.Fitness Tabs for Women · December 2022
I have been taking these vitamins since I was in my 30's. That's a long time ago (not telling how long). I have always enjoyed great health, and I wouldn't change for anything! Please kee…
Teresa B.Fitness Tabs for Women · December 2022
Taken these’s supplements for years ! Work well for me
Albert G.Stress Defense Performance Tabs · November 2022
I'm 62 years old and have taken many vitamins over the years, but this is the only vitamin I have ever taken that actually makes me feel healthier.
DavidFitness Tabs for Men · September 2022
I've been taking/drinking Vital Factors for at least 20 years and never want to stop. The benefits are amazing! Thank you for making such a great vitamin drink.
Lynn W.VitalFactors · July 2022
I have been a competitive runner for four decades, so my need for strong supplements to keep me going is exceptional. At one time, I to try a lower priced product that seemed like it was…
Steve C.Fitness Tabs for Men · June 2022
Product easy to use, tablet dissolves easier now, and gives me more energy and focus just after a few days of starting it!
Happy G.VitalFactors · May 2022
We have more energy and calmness simultaneously. Great bargain and products
B,C.Fitness Tabs for Women · May 2022
I have more energy and my vision is clearer. My body does not feel tired.
B.C.Wild Blueberry & Bilberry Antioxidants · May 2022
I believe these to be a very good value. At $1.19 per day for vitamins and stress defense for both men and women. Would be even less per day if both parties would be consistent in taking…
Karen K.Fitness Tabs for Men · March 2022
I've been taking these supplements for twenty years and they are the best! As MDR provides the latest information with regard to quality ingredients, you can be sure that you're getting j…
Chris from O.Fitness Tabs for Women · January 2022
I have never taken a product like this before and it really works. Feeling great and healthier. Love it!!
B. F.OnGuard Immune Defense · November 2021
Onguard does me wonders, especially in the winter time. Having two homes where I eat off one of my property during harvest time and in the winter, I stay fit with my Onguard
Karen and Bob, G.OnGuard Immune Defense · November 2021
These were recommended to me by my uncle who looks like he's in his 40s but is well into his 50s. These will wake you up and make you feel great without giving you the jitters. The evenin…
DavidFitness Tabs for Men · October 2021
They work well for me as I workout almost daily and my energy level is really good and I attribute at least part of the credit to MDR Fitness Tabs.
Kelly M.Fitness Tabs for Men · September 2021
I've been using these for over 40 years and they are great!!!
mike H.Fitness Tabs for Men · August 2021
Been taking the MEN'S AM/PM FITNESS TABS for about 30 years. Excellent!!
William S.Fitness Tabs for Men · July 2021

Medical Doctors Research, Sunrise, Florida, since 1984.

That is what MDR stands for, and it is where the company still is — forty-two years on, family-owned, formulating and shipping from the same corner of South Florida.

Physicians, scientists and researchers work on the formulas. Most of what MDR sells today it has sold for decades, in the same shapes: a morning tablet and an afternoon one, a fizzy drink you dissolve in water. The catalogue is small on purpose.

More about MDR
MDR's headquarters building in Sunrise, Florida
MDR VitalFactors

Beyond multivitamins, your age defying energy drink.

VitalFactors is MDR’s effervescent NAD+formula. Drop two in a glass of water each morning — energy, focus, and healthy aging in one fizzy ritual.

VitalFactors box beside a glass of water with the effervescent tablets dissolving
Shop VitalFactors
MDR Fitness Tabs

Your Daily AM + PM Nutrition System.

The original multivitamin, split into a morning and an afternoon tablet — one formula for men, one for women.

MDR Fitness Tabs for Men — AM and PM bottlesMDR Fitness Tabs for Women — AM and PM bottles
Shop Men’sShop Women’s
FAQ

Good to know.

What makes MDR different from other supplement brands?

Since 1984, Medical Doctors Research has developed advanced nutrition formulas with input from scientists and nutrition researchers. The focus is ingredient quality, balanced dosing, and formulas built for daily use — not generic, one-size-fits-all supplementation.

Can I take Fitness Tabs and VitalFactors together?

Yes — they're designed to pair. Fitness Tabs are your daily vitamin and mineral foundation; VitalFactors adds effervescent NAD+, antioxidant, and healthy-aging support on top. Many MDR customers take both.

How do I know which MDR product is right for me?

Start with your main goal — daily foundation, energy and focus, healthy aging, joint support, immune support, heart health, digestion, vision, or skin support — and choose the formula that matches what you're trying to improve.

What is MDR's return policy?

MDR offers a satisfaction guarantee. Please see our Refund and Returns policy for current details.

Are MDR products doctor developed?

Yes. MDR formulas are developed with input from scientists and researchers across nutrition, aging, sports medicine, biochemistry, food science, and public health. The goal is practical, balanced formulas built around real daily health needs.

Clinical nutrition,
refined since 1984.

Forty-two years. One daily routine, refined every year. That’s the whole offer.

Doctor-formulated · Free US shipping on Subscribe & Save or 3+ items