One scoop a day for the body and the brain.
PowerFactors puts three things into one level scoop: 5 grams of creatine monohydrate, 250 mg of NMN (nicotinamide mononucleotide) and 100 mg of magnesium from magnesium bisglycinate. The label also lists 100 mg of collagen peptides. There is no sugar and there are no calories.
We made it for people who would rather take one thing than three. If you are over 50, you have probably heard about creatine for strength, NMN for NAD+, and magnesium as a mineral many of us run short of. PowerFactors puts all three in one jar, with the creatine and NMN at the daily amounts used in human studies.
Creatine, 5 grams
Creatine is one of the most studied supplements there is. Your muscles use it to make quick energy for short, hard efforts like lifting, climbing stairs or getting up out of a chair. In studies of adults over 50 who did strength training, the people taking creatine gained more strength and lean muscle than the people training alone.† Your brain uses creatine too, and the early research on memory is encouraging, though the effects so far are modest.†
NMN, 250 mg
NMN is the building block your cells use to make NAD+, a molecule involved in turning food into energy, and NAD+ levels tend to fall as we get older. In placebo-controlled studies, 250 mg of NMN a day for 12 weeks raised NAD+ levels in the blood of healthy adults and was well tolerated.† What that means for how you feel day to day is still being studied, and we would rather tell you that plainly.
Magnesium, 100 mg
Magnesium supports normal muscle and nerve function and energy production.† About half of Americans get less of it from food than they should. The 100 mg in a scoop is a top-up, about a quarter of the daily value, in the bisglycinate form.
How to take it
Stir one level scoop into a glass of juice or your favorite protein shake, once a day. A glass of orange juice in the morning works well. Take it every day: creatine builds up in your muscles over three to four weeks of daily use, so give it at least a month.
A jar holds 25 servings. On Subscribe & Save a new jar ships every 4 weeks, and you can change that to every 3 weeks or every month in your account.
What it’s for†: Energy. Focus and memory. Muscle strength. Healthy aging. Those are the four words on the jar, and they describe the normal body functions these ingredients support. How strong the research is differs a lot between them: it is strongest for muscle strength alongside regular exercise, and early for focus and memory. The details, with the studies, are below.
The full facts panel from the jar is on this page. Further down this page you will find what the research shows at these amounts, with links to the studies, and answers to the questions people ask most. If PowerFactors is not for you, it is covered by MDR’s 90-day satisfaction guarantee.
What the research shows at these amounts
Here is what published human studies have found for each ingredient at or near the amount in one scoop, and what they have not found. Where a study used a different amount, we say so. These are studies of the single ingredients, not of PowerFactors itself.
Creatine monohydrate, 5 g
Creatine monohydrate is one of the most studied supplements there is. Research uses 3 to 5 grams a day to fill and keep up the creatine stores in muscle, which takes about three to four weeks of daily use. The International Society of Sports Nutrition reviewed the safety research and found it well tolerated in healthy people.
In adults over 50 who did resistance training, two analyses that pooled the trials found more gains in strength and lean muscle with creatine than with training alone.
Your brain uses creatine too. A 2023 analysis that pooled eight trials found a small overall benefit to memory, larger in adults aged 66 to 76, though the trials differed a lot. In a six-week trial of 123 adults taking 5 grams a day, the effect on thinking tests was small and fell short of statistical significance.
What it does not show: Most of the strength research pairs creatine with regular resistance exercise. The brain research is early and the effects so far are modest.
- Kreider et al., Journal of the International Society of Sports Nutrition (2017). Position stand on creatine: 3 to 5 g a day maintains muscle stores; safe and well tolerated in healthy people in short and long-term use.
- Chilibeck et al., Open Access Journal of Sports Medicine (2017). Meta-analysis of 22 trials, 721 adults with average ages of 57 to 70 doing resistance training: creatine added about 1.4 kg of lean mass and more chest and leg press strength than training alone.
- Devries and Phillips, Medicine & Science in Sports & Exercise (2014). Meta-analysis of 357 older adults (average age about 64) over about 12 weeks of training: creatine improved chest press, leg press and the chair-stand test; several other strength measures did not differ.
- Prokopidis et al., Nutrition Reviews (2023). Meta-analysis of 8 trials in healthy people: a small overall benefit to memory, larger in adults aged 66 to 76; results varied widely between trials.
- Sandkühler et al., BMC Medicine (2023). 123 adults, 5 g a day for six weeks against placebo: a small effect on a memory test that did not reach statistical significance, and none on a reasoning test.
NMN (nicotinamide mononucleotide), 250 mg
Your cells use NMN to make NAD+, a molecule involved in turning food into energy. NAD+ levels tend to fall as we get older.
In a 12-week placebo-controlled trial of 30 healthy adults, 250 mg of NMN a day raised NAD+ in the blood, and no adverse effects were seen in the 15 people taking it. In a trial of men aged 65 and over (42 enrolled; a supplement mix-up left 20 in the 12-week analysis), the same amount also raised blood NAD+; walking speed and left-hand grip strength improved slightly, muscle mass did not change, and the authors said larger studies are needed.
In September 2025 the FDA concluded that NMN is not excluded from the definition of a dietary supplement. That removed the drug-exclusion barrier. It is not an FDA approval: the FDA does not approve supplements for safety or effectiveness, and makers remain responsible for both.
What it does not show: Raising NAD+ in the blood is well documented. What that means for how you feel or function day to day has not been shown in large trials. A 24-week trial published in September 2026 gave adults aged 65 and over five times this amount (1,250 mg a day): blood NAD+ rose, but hearing and physical performance did not improve.
- Okabe et al., Frontiers in Nutrition (2022). 30 healthy adults, 250 mg a day or placebo for 12 weeks: whole-blood NAD+ rose with NMN; no adverse effects or abnormal lab results were seen in the 15 taking NMN.
- Igarashi et al., npj Aging (2022). 42 healthy men aged 65 and over enrolled (20 in the 12-week analysis after a supplement allocation error), 250 mg a day or placebo: blood NAD+ rose; small gains in gait speed and left grip, no change in body composition. Exploratory results the authors say need larger studies.
- Igarashi et al., npj Aging (2026). Adults aged 65 and over, 1,250 mg a day or placebo for 24 weeks: NAD+ and related compounds rose; no significant improvement in hearing (the main measure) or physical performance.
- U.S. FDA response to citizen petition FDA-2023-P-0872 (September 29, 2025). FDA concluded that NMN is not excluded from the dietary supplement definition, because it was sold as a supplement before it was studied as a drug.
Magnesium (as magnesium bisglycinate), 100 mg
Magnesium supports normal muscle and nerve function and the body's energy production. Adults need 310 to 420 mg a day, and about half of Americans get less than they should from food.
100 mg is a top-up: about a quarter of the daily value, and well under the 350 mg a day the NIH sets as the upper limit for magnesium from supplements.
What it does not show: 100 mg is about a quarter of a day's need, so food is still the main source.
- NIH Office of Dietary Supplements, Magnesium fact sheet for health professionals. Recommended intakes (310 to 420 mg for adults), the 350 mg upper limit for supplemental magnesium, the finding that 48% of Americans take in less than the average requirement from food, and interactions with some antibiotics and bisphosphonates.
Collagen peptides, 100 mg
Collagen peptides are listed on the label at 100 mg. That is far below the 2.5 to 10 grams a day used in most collagen studies, so we make no claims for them.
- Pu et al., Nutrients (2023). Review of 26 collagen trials: most used 2.5 to 10 g a day; the lowest amount in any trial was about 0.4 g.
The combination
No clinical trial has tested PowerFactors or this exact combination. What it offers is convenience: creatine, NMN and magnesium in one scoop instead of three separate products.
What a scoop costs
A jar holds 25 scoops. On Subscribe & Save it is $53.96 a jar, about $2.16 a scoop, with free shipping, delivered every 4 weeks. Bought once, a jar is $59.95, about $2.40 a scoop, plus $6.95 shipping unless the order has 3 or more items.
If you already buy creatine, NMN and magnesium separately and are happy with them, you may not need PowerFactors. If creatine is all you want, plain creatine monohydrate costs less.
Frequently asked.
Adults, especially over 50, who want creatine, NMN and magnesium in one daily scoop instead of three separate products. It suits people who do some kind of strength or resistance exercise, because that is where the creatine research is strongest. It is not meant for children, or for use during pregnancy or nursing.
The creatine is the same thing: 5 grams of creatine monohydrate, the form used in most research. PowerFactors adds 250 mg of NMN and 100 mg of magnesium to the same scoop. If creatine is all you want, plain creatine monohydrate costs less.
Stir one level scoop into a glass of juice or your favorite protein shake, once a day. Orange juice is a good choice. Take it every day, because creatine builds up in muscle over three to four weeks of daily use.
A jar holds 25 servings, so 25 days if you take it every day. On Subscribe & Save a new jar ships every 4 weeks. You can change that to every 3 weeks, or to every month if you skip some days, in your account at any time.
5 grams of creatine monohydrate, 250 mg of NMN (nicotinamide mononucleotide), 100 mg of magnesium from magnesium bisglycinate, and 100 mg of collagen peptides. No calories and no sugar. The full panel is on this page, exactly as printed on the jar.
It can. Creatine can raise creatinine, a number doctors use on kidney function tests, without your kidneys working any differently. Tell your doctor you take creatine before any blood work. If you have kidney problems, ask your doctor before using PowerFactors.
In trials, the side effects reported with creatine are mostly mild, such as stomach upset, and it can add a little body weight in the first weeks, mostly water held in muscle. The NMN trials so far have lasted up to 24 weeks, so there is no long-term data beyond that. Stop using it and talk to your doctor if anything bothers you.
Ask your doctor or pharmacist first if you take any prescription medicine. Magnesium can interfere with some antibiotics (tetracyclines and quinolones) and with bisphosphonates, the bone medicines. The NIH advises taking those antibiotics at least 2 hours before or 4 to 6 hours after magnesium, and bisphosphonates at least 2 hours apart from it.
We recommend not using PowerFactors while pregnant or nursing. NMN has not been studied in pregnancy or breastfeeding. Ask your doctor.
Ask your oncologist before taking PowerFactors. NMN has not been studied in people having cancer treatment.
In September 2025 the FDA concluded that NMN is not excluded from the definition of a dietary supplement, because it was sold as a supplement before it was studied as a drug. That is not an FDA approval: the FDA does not approve supplements for safety or effectiveness.
No. Collagen peptides come from animal sources.
MDR offers a 90-day satisfaction guarantee. Return any unused portion within 90 days for a refund of the purchase price (less shipping). Customer Service can walk you through the steps.
What people say.
Further reading
- Creatine After 50: What the Research Shows for Strength and MuscleCreatine has been tested in more than 20 randomized trials in adults over 50 who lift weights. What the trials found, how much to take, which form to buy, and the honest caveats about water weight and kidney tests.
- Creatine and NMN Together: Is There a Reason to Combine Them?We found no trial that tests creatine and NMN together. Here is what each one has going for it, why the pairing makes sense on paper, who a combined product suits, and who should simply buy plain creatine instead.
- How to Take Creatine and NMN: Timing, Mixing and What to Tell Your DoctorWhen to take creatine and NMN, what to stir them into, what happens if you miss a day, and what your doctor should know before your next blood test.
- Creatine and the Brain: What the Evidence Shows So FarThe brain uses creatine to recycle energy, as muscle does, and supplements raise brain creatine a little. The memory research is promising but mixed. Here is what the biggest trial found, where the signals are, and what is still unsettled.
- NMN Supplements: What the Human Studies Show, and What They Don'tNMN raises NAD+ in the blood in human trials, and so far it looks well tolerated. Whether that turns into stronger muscles, better metabolism or more energy in healthy people is another question. A read of the human trials, including the ones with negative results.
- Magnesium Glycinate vs. Other Forms: Which One, and How Much?Glycinate, citrate, oxide: what the different forms of magnesium actually change, how much a supplement should add to your diet, the 350 mg upper limit, and which medications need a few hours of space.
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Warnings & usage
- Do not exceed the recommended dose. Always follow the directions on the product label.
- If you are pregnant, nursing, taking medication, or managing a medical condition, consult your healthcare professional before use.
- Keep out of reach of children.
- Store in a cool, dry place away from direct sunlight. Do not use if the safety seal is broken or missing.
- Discontinue use and consult a healthcare professional if any adverse reaction occurs.
Read the MDR PowerFactors™ report: label, amounts and research
