We have a friend who is 85 years old and has gone through several bouts of cancer and his immune system, as you can imagine is very sensitive and not as strong as he would like it to be. He has a Caregiver and she ended up giving him a cold. He was very upset! We ran over a bottle of OnGuard to him right away, because he had just gotten the cold the day before we spoke with him. We gave him instruction to take 4 capsules (1 every couple of hours) to get it into his system on the first day and the next day, when we called to ask how he was, he siad the following: " I want to thank you so much!!! I feel 1 million times better. I believe I actually don't have the cold anymore and then we instructed him to keep taking 2 per day. He was so excited that he told us, he had already ordered another bottle. Seriously!!! This was the best news of the day for us, that On Guard Immune Defense helped this precious man who had a weakened immune system, stay sttong and healthy that day and from this moment forward!

Product Overview
OnGuard Immune Defense is built around the immune system you rely on every day — the one working quietly in the background while you commute, travel, and move through crowded rooms. The formula pairs colostrum, the antibody-rich first milk from US Grade A dairy cows, with MycoFusion, a patented complex of MaitakeGold 404 and shiitake mushrooms rich in beta-glucans long studied for their role in immune-cell readiness. The work happens through nutrition layered onto a normal diet, not through short-burst herbal stimulation.
Rounding out the blend are two ingredients prized in traditional wellness practice: Lo Han, the sweet Chinese melon used for centuries to support good health, and sacred lotus seed extract, a longevity botanical that supplies protective antioxidants. The result is a wider nutritional footprint than a single-ingredient immune supplement — designed to sit in a daily routine for years, through travel, seasonal change, and the steady demands of a full schedule.
- Colostrum from US Grade A pasteurized dairy delivers naturally occurring immune factors
- Patented MycoFusion blend of MaitakeGold 404 and shiitake mushrooms rich in beta-glucans
- Lo Han and sacred lotus seed round out the formula — designed for steady AM and PM use

Serving size: 1 capsule · 120 servings per container
- Colostrum. First milk from US Grade A pasteurized dairy cows. Naturally rich in immunoglobulins and other immune factors that newborn calves rely on in their first days of life.*
- MycoFusion Mushroom Complex. Patented blend of MaitakeGold 404 (Grifola frondosa) and shiitake (Lentinula edodes) on brown-rice biomass. The maitake fraction (US Patent #5,854,404) is rich in beta-glucans associated with immune-cell activation.*
- Lo Han (Momordica grosvenorii fruit). Sweet Chinese melon used for centuries in traditional wellness practice to support overall good health and longevity.*
- Sacred Lotus Seed Complex. Patented extract from one of the longest-living seeds known to botany. Supplies protective nutrients and antioxidants studied for their role in healthy aging.*
- Other ingredients. Gelatin (capsule), magnesium stearate, silicon dioxide. The Supplement Facts panel is the source of truth on the full list and exact amounts.
Warnings & usage
- Do not exceed the recommended dose. Always follow the directions on the product label.
- If you are pregnant, nursing, taking medication, or managing a medical condition, consult your healthcare professional before use.
- Keep out of reach of children.
- Store in a cool, dry place away from direct sunlight. Do not use if the safety seal is broken or missing.
- Discontinue use and consult a healthcare professional if any adverse reaction occurs.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What people say.
The best defense. Started taking it at the beginning of Covid. Haven’t getting sick. Period
I was with my Husband in the hospital for 8 months. I felt very down and without energy and I also started taking MDR Stress Defense and I felt better and with more energy. I have been taking the OnGuard Immune defense for a year and stayed well all year despite everything going on around me! I feel very safe with this Immune defense formula.