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Product Overview

OnGuard Immune Defense is built around the immune system you rely on every day — the one working quietly in the background while you commute, travel, and move through crowded rooms. The formula pairs colostrum, the antibody-rich first milk from US Grade A dairy cows, with MycoFusion, a patented complex of MaitakeGold 404 and shiitake mushrooms rich in beta-glucans long studied for their role in immune-cell readiness. The work happens through nutrition layered onto a normal diet, not through short-burst herbal stimulation.

Rounding out the blend are two ingredients prized in traditional wellness practice: Lo Han, the sweet Chinese melon used for centuries to support good health, and sacred lotus seed extract, a longevity botanical that supplies protective antioxidants. The result is a wider nutritional footprint than a single-ingredient immune supplement — designed to sit in a daily routine for years, through travel, seasonal change, and the steady demands of a full schedule.

  • Colostrum from US Grade A pasteurized dairy delivers naturally occurring immune factors*
  • Patented MycoFusion blend of MaitakeGold 404 and shiitake mushrooms rich in beta-glucans
  • Lo Han and sacred lotus seed round out the formula — designed for steady AM and PM use

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

OnGuard Immune Defense Supplement Facts panel — Proprietary Blend 516 mg with colostrum, MycoFusion mushroom complex, Lo Han, and sacred lotus seed

Serving size: 1 capsule · 120 servings per container

  • Colostrum. First milk from US Grade A pasteurized dairy cows. Naturally rich in immunoglobulins and other immune factors that newborn calves rely on in their first days of life.*
  • MycoFusion Mushroom Complex. Patented blend of MaitakeGold 404 (Grifola frondosa) and shiitake (Lentinula edodes) on brown-rice biomass. The maitake fraction (US Patent #5,854,404) is rich in beta-glucans associated with immune-cell activation.*
  • Lo Han (Momordica grosvenorii fruit). Sweet Chinese melon used for centuries in traditional wellness practice to support overall good health and longevity.*
  • Sacred Lotus Seed Complex. Patented extract from one of the longest-living seeds known to botany. Supplies protective nutrients and antioxidants studied for their role in healthy aging.*
  • Other ingredients. Gelatin (capsule), magnesium stearate, silicon dioxide. The Supplement Facts panel is the source of truth on the full list and exact amounts.
From customers

What people say.

5.0
★★★★★
28 verified reviews
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★★★★★MDR.com

I have never taken a product like this before and it really works. Feeling great and healthier. Love it!!

B. F.
★★★★★MDR.com

Thanks to MDR!!! Feeling better then ever since taking this wonderful formula!!

Lilly V.
★★★★★MDR.com

Onguard does me wonders, especially in the winter time. Having two homes where I eat off one of my property during harvest time and in the winter, I stay fit with my Onguard

Karen and Bob, G.
Warnings & usage
  • Do not exceed the recommended dose. Always follow the directions on the product label.
  • If you are pregnant, nursing, taking medication, or managing a medical condition, consult your healthcare professional before use.
  • Keep out of reach of children.
  • Store in a cool, dry place away from direct sunlight. Do not use if the safety seal is broken or missing.
  • Discontinue use and consult a healthcare professional if any adverse reaction occurs.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.